Paul Pogba has been recalled to a Manchester United starting line-up for the first time in three Premier League matches.
The France midfielder was restricted to a substitute role in the 4-1 win over Newcastle and goalless draw against Chelsea.
He lines up in a diamond midfield alongside Fred, Scott McTominay and Bruno Fernandes.
Marcus Rashford, who came off the bench to score a hat-trick in the 5-0 midweek win over RB Leipzig, starts up front alongside Mason Greenwood.
Edinson Cavani has been forced to wait for his full Manchester United debut as he joins Donny van de Beek on the bench.
Meanwhile, Arsenal’s £45million summer signing Thomas Partey will hope to feature in a first Premier League win with his new club.
He has appeared in 1-0 defeats to Man City and Leicester.
Willian, who has missed the last three games through injury, returns to the front three alongside Pierre-Emerick Aubameyang and Alexandre Lacazette.
Manchester United XI: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Pogba, Fernandes, Rashford, Greenwood.
Substitutes: Henderson, Cavani, Mata, Matic, Williams, Van de Beek, Tuanzebe.
Arsenal XI: Leno, Holding, Gabriel, Tierney, Bellerin, Partey, Elneny, Saka, Willian, Lacazette, Aubameyang.
Substitutes: Runarsson, Ceballos, Maitland-Niles, Pepe, Mustafi, Nketiah, Xhaka.
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